Pharmacodynamics of acetaminophen

- Oct 25, 2017 -

Pharmacodynamics This product is acetanilide antipyretic analgesics. Through the inhibition of cyclooxygenase, selective inhibition of hypothalamic thermoregulation of central prostaglandin synthesis, leading to peripheral vascular dilatation, sweating and antipyretic effect, the antipyretic effect and aspirin similar; by inhibiting the synthesis of prostaglandins and other And release, improve pain threshold and play an analgesic effect, are peripheral analgesics, the role of aspirin than weak, only mild to moderate pain effective. This product has no obvious anti-inflammatory effect.

Pharmacokinetics After oral administration of the gastrointestinal tract from the gastrointestinal tract quickly, completely (after high carbohydrate diet may reduce the absorption), absorbed in the body after the distribution of uniform, about 25% and plasma protein binding. A small amount (blood concentration <60μg / ml) and protein binding is not obvious, a large number or a large amount of poisoning rate is higher, up to 43%. 90 ~ 95% of the goods in the liver metabolism, mainly with glucuronic acid, sulfuric acid and cysteine binding. The intermediate metabolites have toxic effects on the liver. Half-life β is generally 1 to 4 hours (2 hours on average), renal insufficiency, but in some patients with liver disease may be extended, the elderly and newborns may be extended, children are shortened. 0.5 to 2 hours after oral administration of plasma concentration up to the peak, the dose of 650mg or less when the plasma concentration of 5 ~ 20μg / ml, the duration of 3 to 4 hours. Lactation during the women taking the goods 650mg, 1 to 2 hours reported milk concentration of 10 ~ 15μg / ml; half-life β is 1.35 ~ 3.5 hours. The goods mainly with glucuronic acid in the form of excretion from the kidneys, about 24 hours within about 3% with the original shape with the urine.


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